Finding the right moisturiser when you are dealing with eczema can feel overwhelming. Walk into any pharmacy and you will see shelves of creams, ointments, and gels, all promising to help. The truth is, there is no single “best” option. What works for one person may not suit another, and sometimes it takes a little trial and error.
What does help is starting with tried and trusted emollients that are widely recommended in the UK. Below are five of the most commonly used moisturisers for eczema relief, all fragrance-free and designed to soothe dry, itchy, and irritated skin.
E45 Moisturising Cream

A long-standing favourite in many households, E45 is easy to find in supermarkets and chemists. It is a mid-weight cream made from paraffin oils that help lock in moisture. Many people like it because it spreads easily, sinks in reasonably quickly, and comes in handy pump bottles.
Good for: everyday moisturising and those who prefer a familiar, widely available brand.
Consider: some versions contain lanolin derivatives, which can cause irritation in people sensitive to lanolin.
Cetraben Cream

Cetraben is specially made for eczema-prone skin. It combines paraffin with glycerol, which draws water into the skin and helps it feel softer. One practical advantage is the airless pump bottles, which reduce mess and contamination.
Good for: families who want a reliable, no-frills cream that can be used on both adults and children.
Consider: it contains cetostearyl alcohol, which very occasionally causes reactions.
Doublebase Gel

Not everyone enjoys creams or ointments, especially if they feel greasy. Doublebase Gel is a lighter option that still delivers a good level of oil. The gel texture makes it a popular choice for daytime use or for hands that need frequent reapplication.
Good for: people who dislike heavy creams, or need a lighter emollient during the day.
Consider: it still contains paraffin, so follow fire safety precautions, as with all emollients.
Epaderm Cream

Epaderm is a versatile option because it doubles as both a moisturiser and a soap substitute. That means you can use it directly on your skin or in place of regular soap, which is helpful since ordinary soap often dries out eczema-prone skin. It is safe for all ages, including babies.
Good for: households that want one product for both cleansing and moisturising.
Consider: contains chlorocresol, a preservative that can occasionally irritate sensitive skin.
Diprobase Cream

Diprobase has been trusted for many years as a go-to emollient for dry, inflamed skin. It is another paraffin-based cream, widely available in large pump bottles.
Good for: those who want a reliable, traditional cream that does not sting and is easy to find.
Consider: like Epaderm, it contains chlorocresol and cetostearyl alcohol, which may irritate a small number of users.
Using emollients effectively
Whichever cream you choose, the way you use it matters just as much as the product itself. Apply liberally and often, at least twice a day, and more during flare-ups. Do not rub it in like a lotion; smooth it gently in the direction of hair growth. If you are using topical steroids as well, leave at least 20 minutes between applications.
It is also important to use your emollient as a soap substitute or cleanser. Regular soap and bubble baths can strip the skin and make eczema worse. Finally, remember that all emollients, even paraffin-free ones, can soak into fabrics and make them more flammable, so keep away from naked flames and wash clothing and bedding regularly.
Quick Comparison Table
Product | Texture | Key Ingredients | Best For | Watch-outs |
---|---|---|---|---|
E45 Cream | Cream | Paraffin oils, some lanolin | Everyday use, wide availability | Lanolin sensitivity in some versions |
Cetraben Cream | Cream | Paraffin, glycerol | Families, airless pump packaging | Cetostearyl alcohol sensitivity |
Doublebase Gel | Gel | Liquid paraffin, isopropyl myristate | Lighter feel, daytime use | Paraffin fire-safety precautions |
Epaderm Cream | Cream | Paraffin, glycerine, chlorocresol | Dual use as moisturiser and cleanser | Rare reactions to preservative |
Diprobase Cream | Cream | Paraffin, cetostearyl alcohol, chlorocresol | Long-trusted option, easy to source | Rare irritation from ingredients |